Tell Tale Games is a new company formed by the team that was working on Sam & Max 2. And on their products page, they're saying...
We've quietly begun development on an exciting license that we can't wait to tell you about! Well, actually we HAVE to wait to tell you about it, but we can tell you it's something many of you already know and love, and that Telltale's only a part of the exciting things that are brewing around it.
Speculation is, of course, ripe that this could be Sam & Max 2, but who knows?